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TB-500 (Thymosin Beta-4): Research Profile of the Actin-Binding Peptide

PEPMAKE Research Team (Laboratory & Content Team)
⏱️ 6 min read
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TB-500 (Thymosin Beta-4): Research Profile of the Actin-Binding Peptide

Short answer

TB-500 is a fragment of thymosin beta-4, a naturally occurring 43-amino-acid protein that binds actin. Because actin controls cell shape and movement, thymosin beta-4 is studied in cell migration and tissue remodeling research models. TB-500 is sold as a lyophilized research powder.

What is thymosin beta-4?

Thymosin beta-4 is one of the most abundant actin-binding proteins in cells. It keeps actin monomers available for building the cytoskeleton - the internal scaffold that lets cells change shape and move [1].

TB-500 refers to a fragment of this protein used in research. Because the fragment retains actin-binding activity, it is used as a tool in studies of cell motility and related pathways.

What the research shows

  • Cell migration - thymosin beta-4 promotes actin polymerization, which cells need to move [1][2].
  • Cardiac repair models - a landmark Nature paper showed thymosin beta-4 activates integrin-linked kinase and supports cardiac cell migration and survival in experimental models [1].
  • Dermal research - wound and tissue remodeling models in the literature.
  • Neural research - recent work reports thymosin beta-4 promotes axon regeneration in zebrafish models through actin binding [2].
  • Key facts at a glance

    PropertyDetail
    Full proteinThymosin beta-4 (43 amino acids)
    Research formTB-500 fragment
    Main function studiedActin binding and cell migration
    Research themesCardiac, dermal, neural repair models
    Typical formLyophilized powder
    Purity expectation99%+ by HPLC

    What to check before buying TB-500

  • Identity - mass spectrometry must match the thymosin beta-4 fragment sequence.
  • Purity - 99%+ by HPLC with chromatogram.
  • Batch COA - per-batch certificate.
  • Lyophilized powder - stable research form.
  • RUO label - laboratory research use only.
  • Compare BPC-157 vs TB-500 if you are deciding between the two peptides, or browse TB-500 product options.

    FAQ

    What is TB-500?

    A research fragment of thymosin beta-4, a 43-amino-acid actin-binding protein.

    What is thymosin beta-4?

    A small, abundant protein that binds actin monomers and supports cell movement.

    How is TB-500 studied?

    In cell migration, actin dynamics, cardiac and dermal repair models.

    Is TB-500 for human use?

    No, laboratory research use only.

    References

  • Bock-Marquette I. et al. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature (2004). Nature article
  • Thymosin beta4 promotes zebrafish Mauthner axon regeneration by facilitating actin polymerization through binding to G-actin (2024). PubMed entry
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