PE-22-28 Research Compound (PE)

"Premium grade PE-22-28 validation."

PE-22-28 is a seven-amino-acid peptide with the sequence GVSWGLR (molecular weight ~774 Da), a shortened analog of spadin that acts as a potent inhibitor of the TREK-1 two-pore-domain potassium channel. Shortened spadin analogs including PE-22-28 were characterized for their TREK-1 inhibition and in vivo activity in antidepressant-research models (Djillani et al., Front Pharmacol 2017, PMID 28955242). PE-22-28 research peptide is supplied lyophilized at ≥99% purity verified by HPLC, with identity confirmed by mass spectrometry and a batch-specific Certificate of Analysis (COA) included. Store lyophilized powder at −20 °C, protected from light and moisture. For laboratory research use only — not for human or animal consumption.