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Epitalon (Epithalon): Research Profile of the Tetrapeptide

PEPMAKE Research Team (Laboratory & Content Team)
⏱️ 5 min read
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Epitalon (Epithalon): Research Profile of the Tetrapeptide

Short answer

Epitalon (also written Epithalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. It has been studied since the 1990s in telomere biology, pineal gland research and longevity-related models. It is sold as a lyophilized research powder for laboratory use only.

Structure and origin

Epitalon is one of the shortest research peptides on the market - just four amino acids: alanine, glutamic acid, aspartic acid and glycine. It was designed by the Russian researcher V. Khavinson and colleagues, who studied short peptides derived from tissue extracts and their effects on cellular aging models.

A 2003 study in the Bulletin of Experimental Biology and Medicine reported that Epithalon induced telomerase activity and telomere elongation in human somatic cell cultures [1]. Telomeres are the protective caps at the ends of chromosomes, and telomerase is the enzyme that maintains them - which is why Epitalon appears in longevity research.

Research themes

  • Telomere biology - telomerase activity and telomere length in cell models [1].
  • Pineal gland research - regulation of melatonin-related pathways in animal models.
  • Cellular aging models - gene expression changes associated with cell senescence.
  • Peptide bioregulation - how short peptides modulate cellular function.
  • What to know before buying

    CheckWhy it matters
    Identity (MS)Confirms the exact Ala-Glu-Asp-Gly sequence
    Purity (HPLC)99%+ for reliable experiments
    Batch COATraceable quality per batch
    Lyophilized formBetter stability in shipping and storage
    RUO labelLaboratory research use only

    FAQ

    What is Epitalon?

    A synthetic tetrapeptide (Ala-Glu-Asp-Gly) studied since the 1990s.

    What research has been done?

    Published work includes telomerase activity in human cell cultures and pineal gland research models.

    Is Epitalon for human use?

    No, laboratory research use only.

    What should I check when buying?

    Batch COA, HPLC purity, MS identity and RUO labeling.

    References

  • Khavinson V.Kh. et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine (2003). PubMed entry
  • See Epitalon product options and the longevity research category for specifications.

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