Short answer
MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA. It belongs to a family of mitochondrial-derived peptides (MDPs) and is studied in metabolic, exercise and mitochondrial research models. It is sold as a lyophilized research powder for laboratory use only.
What is MOTS-c?
MOTS-c was first described in a 2015 Cell Metabolism study that identified a short open reading frame inside the mitochondrial 12S rRNA gene [1]. In other words, a small peptide is encoded not by the nuclear genome but by the mitochondria themselves.
The peptide is 16 amino acids long and is highly conserved. Its discovery opened a research area asking how mitochondria communicate with the rest of the cell through small peptides [1][2].
What researchers study
MOTS-c appears in the literature across several themes:
Key facts at a glance
| Property | Detail |
|---|---|
| Type | Mitochondrial-derived peptide |
| Length | 16 amino acids |
| Source | Encoded in mitochondrial 12S rRNA |
| Research themes | Metabolism, exercise, mitochondrial signaling |
| Typical form | Lyophilized powder |
| Purity expectation | 99%+ by HPLC |
What to check before buying MOTS-c
You can review MOTS-C product options and verify batch documents on the quality portal.
FAQ
What is MOTS-c?
A 16-amino-acid peptide encoded by mitochondrial DNA, part of the mitochondrial-derived peptide family.
What does MOTS-c stand for?
Mitochondrial open reading frame of the 12S rRNA type-c.
How is MOTS-c studied?
In cell and animal models of metabolism, exercise adaptation, insulin signaling and mitochondrial function.
Is MOTS-c for human use?
No, it is a lyophilized research powder for laboratory research only.